National Institute of Dental and Craniofacial Research (NIDCR)

National Institute of Dental and Craniofacial Research (NIDCR) Clinical Trials

Clinical trials are research studies involving people. They seek to answer specific scientific questions to find better ways to prevent, detect, or treat diseases, or to improve care for people with diseases. Each clinical trial follows a set of strict scientific guidelines called a protocol. Each trial also has its own guidelines for who can participate, called eligibility criteria.

Clinical trials are a critical part of the research process. In oral health research, for example, a clinical trial is under way to find out if periodontal (gum) disease contributes to cardiovascular disease. In another study, researchers are looking at the natural history of salivary gland dysfunction to help identify the long-term course of this disorder and its effects on the mouth, oral function, and overall health.